Matchups › Cassiopeia › vs Zoe

Cassiopeia vs Zoe

CassiopeiaYOU · MID
ZoeENEMY · MID
VS
Skill matchupPre-6 MediumPost-6 MediumTake Teleport

How to play it

Cleanse her E
Her E is her biggest threat: it's worth Cleansing unless she can't follow up with a long-range Q.
Fight on her CDs
All-in when her abilities are down: with no stolen W spell and E on CD she has no burst or escape.
Don't hug minions
Her Q hits an area around minions and does more damage the further it travels: walk off the wave when she Qs.
Never fight her while she has a stolen spell from W: it gives her extra move speed and damage.
Runes
SORCERYSORCERY
Summon Aery
Arcane Comet
Stormraider's Surge
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
TeleportTELEPORT
Items
Start
Core
Last 30 days Emerald+ - 50% WR - 768 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXEEQQWW
Cassiopeia · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Cassiopeia vs Zoe in Mid lane is a skill matchup on patch 26.17. The one thing to respect: her E, Sleepy Bubble, it's her biggest threat and sets up her whole combo.

Cassiopeia matchup data compiled from the contributions of Cassiopeia OTP mainsLeague of Legends assets © Riot Games (Data Dragon).