Matchups › Cassiopeia › vs Annie

Cassiopeia vs Annie

CassiopeiaYOU · MID
AnnieENEMY · MID
VS
Swings with levelsPre-6 MediumPost-6 HardTake Teleport

How to play it

Only fight ult-down
Her ult is her main threat: it does burst damage and keeps attacking, so until you're tanky only fight when it's on cooldown.
Poke from range
Q her from outside her range: her Q and W are outranged by all your abilities, so chip her and bait her spells safely.
Count her stun
After she casts four spells a white swirl appears and her next ability stuns: her targeted Q makes it very reliable, so back off when she's charged.
Never all-in while her ult is up: until you're tanky enough her burst kills you, and Tibbers only gets stronger if she dies.
Runes
SORCERYSORCERY
Summon Aery
Arcane Comet
Stormraider's Surge
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
TeleportTELEPORT
Items
Start
Core
Last 30 days Emerald+ - 43% WR - 511 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXEEQQWW
Cassiopeia · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Cassiopeia vs Annie in Mid lane is a lane that swings with levels on patch 26.17. The one thing to respect: her ult (Tibbers) is the whole matchup, it bursts you and keeps attacking, so only fight when it's down.

Cassiopeia matchup data compiled from the contributions of Cassiopeia OTP mainsLeague of Legends assets © Riot Games (Data Dragon).