Matchups › Cassiopeia › vs Syndra

Cassiopeia vs Syndra

CassiopeiaYOU · MID
SyndraENEMY · MID
VS
Heavily unfavoredPre-6 HardPost-6 HardTake Teleport

How to play it

Don't line up with spheres
Avoid lining up with her Dark Spheres: her low-cooldown E chunks you and stuns, often set up by her hard-to-dodge W slow.
Don't trade Q's late
Post level 8, don't trade Q for Q: hers costs less mana and does more damage, unless you can dodge hers or need the CS.
Punish her E on cooldown
When her E is down (or you'll burn summoners to dodge it), you have a window to play aggressive.
Never step into her 675-range ult unless you're tanky enough to survive the burst.
Runes
SORCERYSORCERY
Summon Aery
Arcane Comet
Stormraider's Surge
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
TeleportTELEPORT
Items
Start
Core
16.14 Emerald+ - 46% WR - 706 games
Skill order
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QQQQQ
WWWWW
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RRR
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Cassiopeia · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Cassiopeia vs Syndra in Mid lane is a hard lane on patch 26.17. The one thing to respect: respect her E, she chunks you with it and can stun off the Dark Spheres around you.

Cassiopeia matchup data compiled from the contributions of Cassiopeia OTP mainsLeague of Legends assets © Riot Games (Data Dragon).