Matchups › Cassiopeia › vs Lissandra

Cassiopeia vs Lissandra

CassiopeiaYOU · MID
LissandraENEMY · MID
VS
Favors youPre-6 EasyPost-6 EasyTake Teleport

How to play it

Dodge her Q line
Her Q is her main damage and still hits soft: don't stand in line between her and your minions (it gains range), and your Q outranges it at 825.
Punish her E on CD
While her E is down she can only escape or reach you by Flashing: that's the window to commit and all-in.
Don't overcommit on R
Her point-and-click R stuns for 1.5s, but she can instead self-cast it for a 2.5s Zhonya's-style stasis: don't dive in for a kill she can just deny.
Never overcommit into her ult range: she can self-cast R for a 2.5s stasis to survive and reset, so a greedy dive just gets punished.
Runes
SORCERYSORCERY
Summon Aery
Arcane Comet
Stormraider's Surge
Deathfire Touch
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
PRECISIONPRECISION
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
TeleportTELEPORT
Items
Start
Core
16.14 Emerald+ - 47% WR - 278 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXEEQQWW
Cassiopeia · Mid · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Cassiopeia vs Lissandra in Mid lane is a favourable lane on patch 26.17. The one thing to respect: her Q is her only real damage, don't line up with your minions, and your Q outranges it anyway.

Cassiopeia matchup data compiled from the contributions of Cassiopeia OTP mainsLeague of Legends assets © Riot Games (Data Dragon).