Matchups › Naafiri › vs Karthus
MATCHUPNaafiri · Mid · Patch 26.14 · Ranked Solo · Updated Jul 22, 2026

Naafiri vs Karthus in Mid lane is a favourable lane on patch 26.14. The one thing to respect: his only real threat is Requiem mid-fight — build Edge of Night and it stops mattering. Below is the exact page the OTP runs — runes, skill max order, summoner spells, item build and the four tips that decide the lane, plus a quick quiz before you lock in.

NaafiriYOU · MIDNAAFIRIthe Hound of a Hundred Bites
KarthusENEMY · MIDKARTHUSthe Deathsinger
VS
Favors youPre-6 EasyPost-6 EasyTake Ignite
How to play it
DO
Watch his ult
The one thing to respect is his ultimate when you dive his laner or fight him — everything else you outpace.
Just pop him
He has no hard CC and dies long before his E ticks meaningful damage — all-in freely.
Dodge his Q
His most damaging regular ability is an easily avoided skillshot that only hits hard on isolated targets.
DON'T
Don't dive his laner without accounting for his ultimate — it's the one thing that can punish you.
Runes
DOMINATIONDOMINATION
Electrocute
Dark Harvest
Hail of Blades
Cheap Shot
Taste of Blood
Sudden Impact
Sixth Sense
Grisly Mementos
Deep Ward
Treasure Hunter
Relentless Hunter
Ultimate Hunter
SORCERYSORCERYuniversal page
Axiom Arcanist
Manaflow Band
Nimbus Cloak
Transcendence
Celerity
Absolute Focus
Scorch
Waterwalking
Gathering Storm
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
No rune change for this matchup — run the universal page, our every-game default.
Spells
FlashFLASH
IgniteIGNITE
Items
Start
Core
Last 30 days Emerald+ - 52% WR - 344 games
Skill order
123456789101112131415161718
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WWWWW
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RRR
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IMPROVE YOUR MACRO

Winning lane is only half the game — rotations, wave control and objective tempo decide the rest. Train the map on MOBA Trainer.
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Naafiri matchup data compiled from the community Naafiri OTP matchup sheetLeague of Legends assets © Riot Games (Data Dragon).