Matchups › Gwen › vs Vayne

Gwen vs Vayne

GwenYOU · TOP
VayneENEMY · TOP
VS
Heavily unfavoredPre-6 HardPost-6 HardTake Ignite

How to play it

W her Condemn
After 6, if she E's you you can W it and look for an all-in: but stealth plus ghost/flash make it a coin-flip, so don't force it.
Poke, then all-in
Trade on your W cooldown when she can't hit back, and only all-in once you've poked her low enough.
Give up CS safely
Let her auto you once to push the wave, then farm safely under tower: give up CS if you must.
Never look to fight her in lane: even an all-in that wins on paper usually loses to her stealth and ghost/flash.
Runes
PRECISIONPRECISION
Press the Attack
Lethal Tempo
Fleet Footwork
Conqueror
Absorb Life
Triumph
Presence of Mind
Legend: Alacrity
Legend: Haste
Legend: Bloodline
Coup de Grace
Cut Down
Last Stand
RESOLVERESOLVE
Demolish
Font of Life
Shield Bash
Conditioning
Second Wind
Bone Plating
Overgrowth
Revitalize
Unflinching
SHARDS
Adaptive
Attack Speed
Ability Haste
Adaptive
Move Speed
Health Scaling
Health +65
Tenacity
Health Scaling
Spells
FlashFLASH
IgniteIGNITE
Items
Start
Core
16.14 Emerald+ - 51% WR - 449 games
Skill order
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QQQQQ
WWWWW
EEEEE
RRR
MAXQQEEWW
Gwen · Top · Patch 26.17 · Ranked Solo · Updated Sep 5, 2026

Gwen vs Vayne in Top lane is a hard lane on patch 26.17. The one thing to respect: her Condemn is her setup, W through it for your only all-in window, and don't force the fight otherwise.

Gwen matchup data compiled from the Gwen OTP community matchup sheetLeague of Legends assets © Riot Games (Data Dragon).